Adaptation “in the Wild”: Ontology-Based Personalization of Open-Corpus Learning Material

Abstract. Teacher and students can use WWW as a limitless source of learning material for nearly any subject. Yet, such abundance of content comes with the problem of finding the right piece at the right time. Conventional adaptive educational systems cannot support personalized access to open-corpus learning material as they rely on manually constructed content models. This paper presents an approach to this problem that does not require intervention from a human expert. The approach has been implemented in an adaptive system that recommends students supplementary reading material and adaptively annotates it. The results of the evaluation experiment have demonstrated several significant effects of using the system on students ’ learning

Adaptation “in the Wild”: Ontology-Based Personalization of Open-Corpus Learning Material

Teacher and students can use WWW as a limitless source of learning material for nearly any subject. Yet, such abundance of content comes with the problem of finding the right piece at the right time. Conventional adaptive educational systems cannot support personalized access to open-corpus learning material as they rely on manually constructed content models. This paper presents an approach to this problem that does not require intervention from a human expert. The approach has been implemented in an adaptive system that recommends students supplementary reading material and adaptively annotates it. The results of the evaluation experiment have demonstrated several significant effects of using the system on students’ learning.\u

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis

Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites <i>Trypanosoma brucei</i> (<i>T.b.</i>) <i>gambiense</i> or <i>T.b.rhodesiense</i> and is invariably fatal if untreated. There are 60 million people at risk from the disease throughout sub-Saharan Africa. The infection progresses from the haemolymphatic stage where parasites invade the blood, lymphatics and peripheral organs, to the late encephalitic stage where they enter the central nervous system (CNS) to cause serious neurological disease. The trivalent arsenical drug melarsoprol (Arsobal) is the only currently available treatment for CNS-stage <i>T.b.rhodesiense</i> infection. However, it must be administered intravenously due to the presence of propylene glycol solvent and is associated with numerous adverse reactions. A severe post-treatment reactive encephalopathy occurs in about 10% of treated patients, half of whom die. Thus melarsoprol kills 5% of all patients receiving it. Cyclodextrins have been used to improve the solubility and reduce the toxicity of a wide variety of drugs. We therefore investigated two melarsoprol cyclodextrin inclusion complexes; melarsoprol hydroxypropyl-͎-cyclodextrin and melarsoprol randomly-methylated-β-cyclodextrin. We found that these compounds retain trypanocidal properties <i>in vitro</i> and cure CNS-stage murine infections when delivered orally, once per day for 7-days, at a dosage of 0.05 mmol/kg. No overt signs of toxicity were detected. Parasite load within the brain was rapidly reduced following treatment onset and magnetic resonance imaging showed restoration of normal blood-brain barrier integrity on completion of chemotherapy. These findings strongly suggest that complexed melarsoprol could be employed as an oral treatment for CNS-stage HAT, delivering considerable improvements over current parenteral chemotherapy

The nuclear imperialism-necropolitics nexus: contextualizing Chinese-Uyghur oppression in our nuclear age

This paper provides a review of the People’s Republic of China’s (PRC) nuclear warfare and uranium mining programs in the Xinjiang Uyghur Autonomous Region. Its scope spans from the PRC’s first nuclear weapon test in Lop Nor, to contemporary issues surrounding in-situ leach uranium mining in the Yili basin, which now provides a third of PRC’s uranium. By exploring these scenarios, a lens can be placed on the parameters and limitations to Uyghur life within a nuclear state. This paper draws on the work of Achille Mbembe’s necropolitics, whereby power is persistently exercised as violence, to consider the entangled aftermath of nuclear imperialism and its effects to Uyghur bodies, environment and culture. While racialized nuclear imperialism presented Uyghur lives as inconsequential to progress in Xinjiang, post-Cold War necropolitics presents Uyghur culture as a direct threat to the progress and values of the PRC sovereign state. This paper proposes that the ongoing exploitation of nuclear Xinjiang provides an additional motivation for state-imposed necropolitical sanctions upon Uyghur people. This paper also presents anew theoretical contribution, the “nuclear imperialism-necropolitics nexus”, which offers away to consider the entangled legacies of spaces of nuclear activity, from nuclear imperialism to the post-Cold War world

The mastaba of Khentika, called Ikhekhi

Includes index.Electronic reproduction.78 p., [43] leaves of plates ill., plans 31 c